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PROCARBAZINE HYDROCHLORIDE |
| Synonyms. Procarbazine hydrochloride; N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride; 1-(p-Isopropylcarbamoylbenzyl)-2-methylhydrazine hydrochloride; 1-Methyl-2-(p- isopropylcarbamoylbenzyl)hydrazine hydrochloride; 1-Methyl-2-p-(isopropylcarbamoyl) benzohydrazine hydrochloride; 2-(p-(Isopropylcarbamoyl)benzyl)-1-methylhydrazine hydrochloride; Chlorhydrate de 1-methyl 2 p (isopropylcarbamoyl)benzyl-hydrazine; Ibenzmethyzin hydrochloride; N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride; N-Isopropyl-alpha- (2-methylhydrazino) -p-toluamide monohydrochloride; N-Isopropyl-p-(2-methylhydrazinomethyl) benzamide hydrochloride; p-(N'-Methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
671-16-9 (net), 366-70-1 (hydrochloride) |
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EINECS RN |
211-582-2 (net), 206-678-6 (hydrochloride) |
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FORMULA |
C12H19N3O·HCl |
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MOLE WEIGHT |
257.76 |
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H.S CODE |
2928.00.2500 |
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SMILES |
c1(C(NC(C)C)=O)ccc(CNNC)cc1.Cl |
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CLASSIFICATION |
Alkylating agent, Antineoplastic, Triazine |
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EXTRA NOTES |
An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. (Mesh) Overall Carcinogenic Evaluation: Group 2A |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
yellowish crystalline powder |
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MELTING POINT |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
Soluble |
| SOLVENT SOLUBILITY | Slightly soluble in ethanol |
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VAPOR DENSITY |
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log P(octanol-water) |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pH |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents. |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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Wikipedia Linking - Procarbazine Google Scholar Search - Procarbazine Drug Information Portal (U.S. National Library of Medicine) - Procarbazine hydrochloride PubChem Compound Summary - Procarbazine Drug Bank - Procarbazine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Procarbazine http://www.ebi.ac.uk/ - Procarbazine http://www.ncbi.nlm.nih.gov/ - Procarbazine http://toxnet.nlm.nih.gov/ |
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| SALES SPECIFICATION | |
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APPEARANCE |
yellowish crystalline powder |
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IDENTIFICATION |
positive (Test A,B) |
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CONTENT |
95.0% ~ 105.0% (on the dried basis) |
| LOSS ON DRYING |
1.0% max |
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HEAVY METALS |
10ppm max |
| RESIDUE ON IGNITION |
0.1% max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
Not regulated |
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| PACKING GROUP | |
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| SAFETY INFORMATION |
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HAZARD OVERVIEW |
Harmful if swallowed. Suspected of causing genetic defects. May cause cancer. May damage fertility or the unborn child. OSHA Hazards: Carcinogen, Harmful by ingestion., Teratogen, Reproductive hazard, Mutagen. Target Organs: Blood, Testes, Kidney, Liver |
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GHS |
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SIGNAL WORD |
Danger |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H302-H341-H350-H360 |
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P STATEMENTS |
P201-P281-P308 + P313 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
45-61-22-68 |
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SAFETY PHRASES |
53-36/37-45 |
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| PACKING |
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